Astelin (azelastine hydrochloride) is a prescription antihistamine nasal spray approved for the treatment of seasonal and perennial allergic rhinitis in adults and children ages 6 years and older. It provides fast-acting, non-sedating relief from nasal symptoms such as sneezing, runny nose, and nasal itching by directly targeting histamine receptors in the nasal passages. Its topical administration minimizes systemic exposure, offering an effective option for patients seeking localized symptom control with a favorable safety profile.

Features

• Contains azelastine hydrochloride 137 mcg per spray
• Available in a metered-dose spray bottle (delivers 200 sprays per 30 mL bottle)
• Rapid onset of action, with symptom relief often beginning within 15 minutes
• Non-sedating formula for daytime use
• Preservative-free formulation (in some markets)
• Compatible with other allergy medications, including oral antihistamines and corticosteroids

Benefits

• Provides rapid and effective relief from allergic rhinitis symptoms, including rhinorrhea, sneezing, and nasal pruritus
• Reduces the need for systemic medications, minimizing risks of drowsiness and other systemic side effects
• Easy-to-use spray applicator ensures precise dosing and direct delivery to affected nasal mucosa
• Suitable for long-term management of perennial allergic rhinitis and seasonal flare-ups
• May be used adjunctively with other allergy treatments for enhanced symptom control
• Improves quality of life by enabling normal daily activities without significant allergy-related interruptions

Common use

Astelin Nasal Spray is commonly prescribed for the management of symptoms associated with seasonal allergic rhinitis (e.g., hay fever) and perennial allergic rhinitis (e.g., allergies to dust mites, pet dander, or mold). It is particularly useful for patients who experience prominent nasal symptoms such as runny nose, sneezing, and itching. Some healthcare providers may also recommend it off-label for vasomotor rhinitis or as part of a combination therapy approach for more complex allergic presentations.

Dosage and direction

For adults and children 12 years and older:
2 sprays per nostril twice daily.

For children 6 to 11 years old:
1 spray per nostril twice daily.

Shake gently before use. Prime the pump before first use or if not used for more than 3 days by releasing 4 sprays into the air until a fine mist appears. Blow nose gently before use. Tilt head slightly forward, insert tip into nostril, and spray toward the outer nasal wall while breathing in gently. Avoid spraying directly toward the nasal septum. Replace cap after each use.

Precautions

• Do not use in children under 6 years of age unless directed by a healthcare provider.
• Avoid contact with eyes; if contact occurs, rinse thoroughly with water.
• Use with caution in patients with renal or hepatic impairment.
• May cause drowsiness in some individuals; assess tolerance before driving or operating machinery.
• Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Discard bottle after 200 sprays, even if it is not completely empty, to ensure accurate dosing.

Contraindications

• Hypersensitivity to azelastine hydrochloride or any component of the formulation.
• History of severe adverse reactions to antihistamines.
• Not recommended for use in patients with severe renal impairment without medical supervision.

Possible side effect

Common side effects may include:

• Bitter taste in the mouth (approximately 20% of users)
• Headache (∼5%)
• Nasal irritation or burning (∼3%)
• Sneezing immediately after application (∼2%)
• Epistaxis (nosebleeds; ∼2%)
• Drowsiness (∼1–2%)

Less common side effects:

• Nausea
• Dizziness
• Dry mouth
• Rhinitis
• Pharyngitis

Rare but serious side effects (seek medical attention if experienced):

• Severe nasal irritation or ulceration
• Signs of allergic reaction (e.g., rash, itching, swelling)
• Difficulty breathing

Drug interaction

• CNS depressants (e.g., alcohol, sedatives): May enhance drowsiness.
• Other antihistamines: Potential for additive sedative effects.
• No clinically significant interactions with CYP450 enzyme inducers or inhibitors have been reported.
• Use caution with other intranasal products; allow sufficient time between administrations to avoid irritation.

Missed dose

If a dose is missed, administer it as soon as possible. If it is nearly time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.

Overdose

Symptoms of overdose may include drowsiness, dizziness, nausea, or vomiting. There is no specific antidote for azelastine overdose. Treatment should be supportive and symptomatic. In cases of accidental ingestion, seek medical attention or contact a poison control center.

Storage

Store at room temperature (15–30°C or 59–86°F). Do not freeze. Keep the bottle tightly closed and protected from light. Keep out of reach of children and pets. Discard any unused medication after the expiration date or after 200 sprays, whichever comes first.

Disclaimer

This information is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

Clinical studies and patient reports indicate high satisfaction with Astelin Nasal Spray for its rapid relief of allergic rhinitis symptoms. Many users appreciate the non-drowsy formula, though some note the bitter taste as a drawback. Overall, it is regarded as an effective and well-tolerated option for nasal allergy management.