Theo-24 Cr: Sustained Bronchodilation for Improved Respiratory Control
| Product dosage: 400mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 120 | $0.37 | $44.38 (0%) | 🛒 Add to cart |
| 180 | $0.35 | $66.57 $62.53 (6%) | 🛒 Add to cart |
| 270 | $0.32 | $99.85 $87.74 (12%) | 🛒 Add to cart |
| 360 | $0.29
Best per pill | $133.13 $103.88 (22%) | 🛒 Add to cart |
Theo-24 Cr (theophylline anhydrous) is an extended-release oral formulation designed to provide 24-hour maintenance therapy for asthma and chronic obstructive pulmonary disease (COPD). As a methylxanthine derivative, it functions as a bronchodilator and respiratory stimulant, offering continuous airway management with once-daily dosing. Its unique delivery system ensures stable serum concentrations, reducing peak-trough fluctuations and minimizing the risk of symptomatic oscillations. This product is indicated for patients requiring long-term control of reversible bronchospasm, particularly those with nocturnal symptoms or exercise-induced limitations.
Features
- Extended-release formulation for 24-hour therapeutic coverage
- Available in 100mg, 200mg, 300mg, and 400mg strength capsules
- pH-independent release mechanism for consistent absorption
- Once-daily dosing regimen to enhance adherence
- Bioavailability approximately 100% under fasting conditions
- Steady-state achieved within 3 days with appropriate dosing
Benefits
- Maintains patent airways for full daily activity participation
- Reduces frequency and severity of nocturnal asthma symptoms
- Decreases reliance on rescue inhalers through proactive management
- Provides predictable pharmacokinetics for stable therapeutic effect
- Supports improved exercise tolerance in obstructive lung diseases
- Enables simplified treatment regimen with single daily administration
Common use
Theo-24 Cr is primarily prescribed for the maintenance treatment of bronchospasm associated with asthma, chronic bronchitis, emphysema, and other COPD variants. It is particularly valuable for patients who experience nighttime awakening due to respiratory symptoms or those requiring continuous bronchodilator coverage throughout the day. The medication is typically incorporated into comprehensive management plans that may include inhaled corticosteroids, environmental control measures, and patient education. Clinical use requires careful patient selection based on pharmacokinetic considerations and monitoring capabilities.
Dosage and direction
Dosage must be individualized based on ideal body weight, smoking status, concurrent medications, and hepatic function. Initial dosing for adults typically ranges from 300-400mg once daily, preferably taken in the morning. Dose titration should occur in increments of 100-200mg every 3 days until optimal therapeutic response is achieved or maximum recommended dosage is reached (900mg daily for adults, 20mg/kg for children, not to exceed 900mg). Administration must occur on an empty stomach, at least 1 hour before or 2 hours after meals, as food significantly alters absorption kinetics. Capsules should be swallowed whole without chewing, crushing, or dividing.
Precautions
Theophylline has a narrow therapeutic index (10-20 mcg/mL), requiring careful monitoring of serum concentrations, especially during dose adjustments and with changing clinical status. Patients with congestive heart failure, liver disease, or prolonged fever require dosage reduction. Elderly patients and neonates exhibit reduced clearance. Smoking increases theophylline metabolism, potentially necessitating higher doses. Concurrent illnesses such as viral infections or pneumonia may alter pharmacokinetics. Patients should avoid excessive caffeine consumption as it may potentiate adverse effects. Regular assessment of clinical response and potential toxicity signs is essential.
Contraindications
Theo-24 Cr is contraindicated in patients with known hypersensitivity to theophylline or any component of the formulation. Additional contraindications include active peptic ulcer disease, uncontrolled seizure disorders, and underlying cardiac arrhythmias (particularly tachyarrhythmias). The product should not be administered to patients who have demonstrated previous theophylline toxicity. Concurrent use with other xanthine derivatives is contraindicated. The extended-release formulation is not appropriate for treatment of acute bronchospasm where rapid onset is required.
Possible side effects
Common adverse reactions (>10%) include nausea, vomiting, headache, and insomnia. Less frequent effects (1-10%) comprise nervousness, restlessness, gastroesophageal reflux, and tachycardia. Serious side effects requiring medical attention include persistent vomiting, cardiac arrhythmias, seizures (particularly without preceding signs of toxicity), and hypersensitivity reactions. Gastrointestinal effects often diminish with continued therapy. Side effect frequency and severity correlate with serum concentrations, emphasizing the importance of therapeutic drug monitoring.
Drug interaction
Theophylline interacts with numerous medications through cytochrome P450 pathways. Potent inhibitors of CYP1A2 (fluvoxamine, ciprofloxacin) and CYP3A4 (macrolide antibiotics, antifungals) can increase theophylline concentrations by 50-100%. Enzyme inducers (phenobarbital, rifampin, carbamazepine) may decrease levels by 30-50%. Theophylline itself may increase the effects of warfarin, lithium, and sympathomimetics while decreasing benzodiazepine efficacy. Concurrent use with beta-blockers may antagonize bronchodilator effects. A comprehensive medication review is essential before initiation and during therapy.
Missed dose
If a dose is missed, it should be taken as soon as possible on the same day. However, if remembered near the time of the next scheduled dose, the missed dose should be skipped entirely. Patients should never double the dose to make up for a missed administration. Consistent timing is crucial for maintaining therapeutic concentrations, so establishing a routine (e.g., with morning tooth brushing) improves adherence. Healthcare providers should be notified if multiple doses are missed, as retitration may be necessary.
Overdose
Theophylline overdose constitutes a medical emergency requiring immediate intervention. Early signs include nausea, vomiting, tachycardia, and tremors. Severe overdose may progress to hypokalemia, hyperglycemia, metabolic acidosis, cardiac arrhythmias, seizures, and death. Serum concentrations above 25 mcg/mL indicate significant toxicity, while levels exceeding 40 mcg/mL are potentially fatal. Treatment involves gastric lavage if presented early, multiple-dose activated charcoal, and supportive care including electrolyte correction and seizure prophylaxis. Hemodialysis may be necessary for severe cases with levels >50-60 mcg/mL.
Storage
Store at controlled room temperature (20-25°C or 68-77°F) in a dry place protected from light and moisture. Keep the container tightly closed and out of reach of children. Do not transfer capsules to other containers as moisture protection may be compromised. Discard any medication that shows signs of capsule damage, discoloration, or unusual odor. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information provides a general overview and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for personalized recommendations regarding medical conditions and treatments. Dosage adjustments should only be made under medical supervision. The manufacturer is not liable for any adverse effects resulting from improper use, dosage miscalculations, or failure to follow prescribing information.
Reviews
Clinical studies demonstrate Theo-24 Cr effectively maintains therapeutic theophylline concentrations with once-daily dosing in approximately 85% of patients. Pulmonary function tests show significant improvement in FEV1 and peak flow measurements compared to placebo. Patient-reported outcomes indicate reduced nighttime symptoms and improved quality of life scores. However, 15-20% of patients require twice-daily dosing due to rapid metabolism. Most reviews emphasize the importance of consistent timing and empty stomach administration for optimal results. Healthcare providers note the convenience of once-daily dosing improves adherence compared to shorter-acting formulations.