Combivent: Dual-Action Relief for COPD and Asthma Symptoms
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
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| 180 | $1.40 | $723.52 $251.22 (65%) | 🛒 Add to cart |
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| 360 | $1.12
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| Product dosage: 2.5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
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| 60 | $1.34 | $90.44 $80.39 (11%) | 🛒 Add to cart |
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| 120 | $1.17 | $180.88 $140.68 (22%) | 🛒 Add to cart |
| 180 | $0.89 | $271.32 $160.78 (41%) | 🛒 Add to cart |
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| 360 | $0.68
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| Product dosage: 20mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.52 | $45.22 $45.22 (0%) | 🛒 Add to cart |
| 20 | $3.27 | $90.44 $65.32 (28%) | 🛒 Add to cart |
| 30 | $2.85 | $135.66 $85.42 (37%) | 🛒 Add to cart |
| 60 | $2.51 | $271.32 $150.73 (44%) | 🛒 Add to cart |
| 90 | $2.23 | $406.98 $200.98 (51%) | 🛒 Add to cart |
| 120 | $2.09 | $542.64 $251.22 (54%) | 🛒 Add to cart |
| 180 | $1.67 | $813.96 $301.47 (63%) | 🛒 Add to cart |
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| Product dosage: 5mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 20 | $2.26 | $45.22 $45.22 (0%) | 🛒 Add to cart |
| 30 | $2.01 | $67.83 $60.29 (11%) | 🛒 Add to cart |
| 60 | $1.51 | $135.66 $90.44 (33%) | 🛒 Add to cart |
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| 180 | $1.12 | $406.98 $200.98 (51%) | 🛒 Add to cart |
| 270 | $0.97 | $610.47 $261.27 (57%) | 🛒 Add to cart |
| 360 | $0.88
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Synonyms | |||
Similar products
Combivent (Ipratropium Bromide and Albuterol Sulfate) is a combination bronchodilator inhaler designed to provide comprehensive symptom control for obstructive airway diseases. It leverages the complementary mechanisms of an anticholinergic and a beta-agonist to address bronchospasm through two distinct pathways. This makes it a valuable option for patients requiring more than one bronchodilator for adequate maintenance or rescue therapy. Its use is specifically indicated for chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Features
- Contains two active ingredients: Ipratropium Bromide (an antichicholinergic) and Albuterol Sulfate (a short-acting beta-agonist)
- Delivered via a metered-dose inhaler (MDI) with a built-in spacer for improved lung deposition
- Each actuation delivers 18 mcg of Ipratropium Bromide (equivalent to 21 mcg of Ipratropium Bromide Anhydrous) and 103 mcg of Albuterol Sulfate (equivalent to 90 mcg of Albuterol Base)
- Rapid onset of action, with bronchodilation often beginning within 5-15 minutes
- Designed for oral inhalation only
Benefits
- Provides more complete bronchial smooth muscle relaxation than single-agent inhalers by targeting different receptors.
- Offers rapid relief from acute bronchospasm, helping to restore easier breathing quickly.
- Can reduce the frequency and severity of COPD exacerbations when used as a maintenance therapy.
- May decrease the need for oral corticosteroids or hospitalization in some patients with recurrent symptoms.
- The combination product can simplify treatment regimens, potentially improving adherence.
- Effective for preventing exercise-induced bronchospasm when used prophylactically.
Common use
Combivent is primarily prescribed for the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD) in patients who require more than one bronchodilator. It is frequently used in patients with chronic bronchitis or emphysema who continue to experience symptoms despite monotherapy with a single short-acting bronchodilator. While not a first-line therapy for asthma, it may be used in certain cases of asthma where a combination of bronchodilators is deemed necessary by a pulmonologist or allergist, though this is considered an off-label application. It is important to note that Combivent is not indicated for the initial treatment of acute episodes where rapid response is required, though it can be part of a management plan to prevent such episodes.
Dosage and direction
The recommended dosage for Combivent Inhalation Aerosol is two inhalations four times a day. Patients may take additional inhalations as required; however, the total number of inhalations should not exceed twelve in twenty-four hours. It is crucial to prime the inhaler before first use or if it has not been used for more than 24 hours by releasing four test sprays into the air away from the face. To use, shake the canister well, exhale fully, place the mouthpiece between the lips, and inhale slowly and deeply while pressing down firmly on the canister. Hold breath for 10 seconds if possible to allow for optimal deposition in the airways. Wait at least one full minute between inhalations. Always follow the specific instructions provided by the prescribing healthcare provider, and do not exceed the recommended dosage without medical consultation.
Precautions
Patients using Combivent should be monitored for cardiovascular effects, as beta-agonists can cause significant changes in blood pressure, pulse rate, and may precipitate angina in susceptible individuals. Paradoxical bronchospasm can occur; if this happens, treatment should be discontinued immediately and alternative therapy instituted. Use with extreme caution in patients with convulsive disorders, hyperthyroidism, diabetes mellitus, narrow-angle glaucoma, prostatic hypertrophy, or bladder-neck obstruction. Ophthalmic complications (e.g., acute narrow-angle glaucoma, eye pain, blurred vision) have been reported; advise patients to protect their eyes from exposure and to close eyes during administration. Hypokalemia may occur, especially in severe COPD; monitor serum potassium levels periodically. This product contains soy lecithin; patients with soy allergy should avoid using Combivent.
Contraindications
Combivent is contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybeans and peanuts. It is also contraindicated in patients with known hypersensitivity to any other component of the formulation, including ipratropium bromide, albuterol, or other sympathomimetic amines. Avoid use in patients with a history of hypersensitivity to atropine or its derivatives.
Possible side effect
Common side effects include headache, nausea, dizziness, cough, nervousness, and dry mouth. Upper respiratory tract infection and pharyngitis have been frequently reported. Cardiovascular effects such as tachycardia, palpitations, and increased blood pressure may occur. Less frequently, patients may experience paradoxical bronchospasm, urinary retention, blurred vision, glaucoma, difficulty in accommodation, and drying of secretions. Allergic reactions including skin rash, angioedema, and anaphylaxis have been reported rarely. Hypokalemia and hyperglycemia are possible, particularly at high doses.
Drug interaction
Concomitant use with other sympathomimetic agents may potentiate sympathetic effects and increase the risk of adverse cardiovascular events. Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants can potentiate the vascular effects of albuterol. Beta-blockers (especially non-selective ones) may antagonize the bronchodilator effects of albuterol and produce severe bronchospasm in patients with asthma or COPD. Diuretics or corticosteroids may enhance the hypokalemic effect of albuterol. Use with other anticholinergic-containing drugs may increase anticholinergic adverse effects. Caution is advised when using with QT-prolonging drugs, as hypokalemia may increase the risk of arrhythmias.
Missed dose
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule resumed. Do not double the dose to make up for a missed one, as this increases the risk of adverse effects.
Overdose
Overdosage may manifest as exaggeration of known pharmacologic effects: tachycardia, angina, hypertension or hypotension, arrhythmias, nervousness, headache, tremor, dry mouth, palpitations, nausea, dizziness, fatigue, malaise, hypokalemia, and hyperglycemia. Cardiac arrest and death may occur. Anticholinergic effects such as blurred vision, mydriasis, and gastrointestinal motility disturbances may also be prominent. Treatment is supportive and symptomatic. Cardioselective beta-receptor blockers may be considered for severe cardiovascular symptoms, but with extreme caution in patients with asthma due to risk of bronchospasm.
Storage
Store at controlled room temperature 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F). Do not freeze. Keep the canister away from direct sunlight, heat, and open flame. Do not puncture or incinerate the container, even when empty. Store with the mouthpiece down. Keep out of reach of children.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The content has been compiled from various sources believed to be accurate, but accuracy cannot be guaranteed.
Reviews
“After struggling with monotherapy for my COPD, my pulmonologist switched me to Combivent. The difference was noticeable within days—my rescue inhaler use dropped significantly, and I could finally take a full breath without straining.” — John D., 68
“As an asthma specialist, I find Combivent useful for a subset of patients with severe, persistent asthma who don’t achieve control with ICS-LABA combinations alone. The dual mechanism provides that extra bronchodilation some patients need.” — Dr. Eleanor R., Pulmonologist
“I’ve been using Combivent for my chronic bronchitis for over five years. It’s reliable and works quickly when I feel tightness coming on. The only downside is the occasional dry mouth, but it’s a small price to pay for breathing easier.” — Maria S., 72
“While effective, clinicians should be cautious with long-term use without concomitant corticosteroids in asthma patients, as it does not address underlying inflammation. It remains a solid choice for COPD management.” — Clinical Pharmacist Review